Populene D analogues: design, concise synthesis and antiproliferative activity.
نویسندگان
چکیده
An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate activity (mean logGI(50) = 0.91) was found. Additionally, compounds with selectivity toward the tumor cell lines NCI-ADR/RES, OVCAR-3, and HT29 were discovered.
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ورودعنوان ژورنال:
- Molecules
دوره 17 8 شماره
صفحات -
تاریخ انتشار 2012